OPC-14523 free base is a potent sigma and 5-HT1A receptor agonist. With a high affinity for sigma receptors (σ1/2 IC50=47/56 nM) and the 5-HT1A receptor (IC50=2.3 nM), along with activity at the 5-HT transporter (IC50=80 nM), it exhibits significant antidepressant-like effects. This compound is valuable for research applications investigating mood disorders and serotonergic signaling pathways.
OPC-14523 free base is a potent sigma and 5-HT1A receptor agonist. With a high affinity for sigma receptors (σ1/2 IC50=47/56 nM) and the 5-HT1A receptor (IC50=2.3 nM), along with activity at the 5-HT transporter (IC50=80 nM), it exhibits significant antidepressant-like effects. This compound is valuable for research applications investigating mood disorders and serotonergic signaling pathways.
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