Fig. 1 · Structure
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OPC-14523 hydrochloride
Sigma/5-HT1A Receptor Agonist
OPC-14523 hydrochloride is a potent agonist of the 5-HT1A receptor, exhibiting high affinity for sigma receptors (σ1/2 IC50=47/56 nM) and the serotonin transporter (IC50=80 nM). This compound demonstrates notable antidepressant-like activity and is valuable for research into mood disorders and neuropharmacology. Its pharmacological profile makes it a useful tool for studies investigating the role of serotonin receptors in depression and anxiety.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Agonist |
| CAS Number | 145969-31-9 |
| Applications | Sigma/5-HT1A Receptor Agonist |
| Formula | C23H29Cl2N3O2 |
| Molecular Weight | 450.40 |
| SMILES | O=C1N(CCCN2CCN(C3=CC=CC(Cl)=C3)CC2)C4=C(C(OC)=CC=C4)CC1.[H]Cl |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.