Fig. 1 · Structure
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Opiranserin hydrochloride
GlyT2/5HT2A Antagonist
Opiranserin hydrochloride is a dual antagonist targeting glycine transporter type 2 (GlyT2) and serotonin receptor 2A (5HT2A), exhibiting IC50 values of 0.86 and 1.3 μM, respectively. In addition, it demonstrates antagonistic activity on recombinant P2X3 receptors with an IC50 of 0.87 μM. This compound is under development as an injectable analgesic for postoperative pain management, making it relevant for research in pain pathways and therapeutic interventions.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Antagonist |
| CAS Number | 1440796-75-7 |
| Applications | GlyT2/5HT2A Antagonist |
| Formula | C21H35ClN2O5 |
| Molecular Weight | 430.97 |
| Synonyms | VVZ-149 hydrochloride |
| SMILES | O=C(C1=CC(OC)=C(OCCCC)C(OC)=C1)NCC2(CCOCC2)N(C)C.[H]Cl |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.