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OPN-9643

TEAD Inhibitor

OPN-9643 is a covalent inhibitor that targets the central palmitate binding pocket of TEAD transcription factors, exhibiting an IC50 of 15 nM. By preventing autopalmitoylation, it effectively reduces TEAD-driven luciferase activity along with the expression of canonical TEAD targets, such as CTGF and CYR61. This compound is valuable for cancer research, particularly in studying melanoma and other TEAD-related pathologies.

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Specifications

Manufacturer	Adooq Bioscience
Actions	Inhibitor
CAS Number	2866423-06-3
Applications	TEAD Inhibitor
Formula	C₁₉H₁₆F₃NO₂
Molecular Weight	347.33
SMILES	C=CC(N1CC2=C(C=CC(OC3=CC=C(C(F)(F)F)C=C3)=C2)CC1)=O

Storage & Solubility

In Vitro Solubility

Reported Solubility

No reported solubility data are available for this product.

Preparing Stock Solutions

Stock preparation is unavailable for this product molecular weight.

Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.

Storage

Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.