Fig. 1 · Structure
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OPN-9652
TEAD Inhibitor
OPN-9652 is a highly potent, orally bioavailable, covalent inhibitor of TEAD, exhibiting an IC50 of 0.005 µM in MSTO-211H cells. By targeting the central palmitate binding pocket of TEADs, OPN-9652 effectively diminishes TEAD-dependent reporter activity and downregulates the expression of key TEAD target genes, including CTGF and CYR61. This compound has been shown to resensitize drug-tolerant SOX10 knockout cells to combined BRAFi and MAPKi treatment, as well as to delay the onset of tumor resistance in a BRAF mutant A375 xenograft model. OPN-9652 is valuable for research in melanoma and related cancer pathways.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 2866423-35-8 |
| Applications | TEAD Inhibitor |
| Formula | C19H15F4NO2 |
| Molecular Weight | 365.32 |
| SMILES | C=CC(N1CC2=C(C=CC(OC3=CC=C(C(F)(F)F)C(F)=C3)=C2)CC1)=O |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.