Fig. 1 · Structure
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Org-12962
5-HT2C Receptor Agonist
Org-12962 is a selective agonist of the 5-HT2C receptor, demonstrating a pEC50 value of 7.01. In addition to its primary target, Org-12962 shows significant efficacy for the 5-HT2A and 5-HT2B receptors with pEC50 values of 6.38 and 6.28, respectively. This compound is notable for its anti-aversive effects observed in rat models of panic-like anxiety, making it a valuable tool for investigating anxiety disorders and related neuropharmacology.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Agonist |
| CAS Number | 132834-56-1 |
| Applications | 5-HT2C Receptor Agonist |
| Formula | C10H11ClF3N3 |
| Molecular Weight | 265.66 |
| SMILES | FC(F)(F)C1=C(N=C(C=C1)N2CCNCC2)Cl |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.