Fig. 1 · Structure
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Org-24598 lithium
GlyT-1 Inhibitor
Org-24598 lithium is a selective inhibitor of glycine transporter 1 (GlyT-1), demonstrating significant binding affinity with a Ki value of 16.9 nM for [3H] CHIBIA-3007 in rat brain membranes. This compound is valuable for research focused on neurotransmission, synaptic modulation, and neuropharmacology, particularly in the context of disorders associated with aberrant glycine signaling. Org-24598 lithium can aid in the exploration of GlyT-1's role in various neurological conditions and potential therapeutic strategies.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 722456-08-8 |
| Applications | GlyT-1 Inhibitor |
| Formula | C19H19F3LiNO3 |
| Molecular Weight | 373.30 |
| SMILES | CN(CC(O[Li])=O)CC[C@@H](OC1=CC=C(C(F)(F)F)C=C1)C2=CC=CC=C2 |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.