Orvepitant maleate is a potent and selective antagonist of the neurokinin-1 (NK-1) receptor, exhibiting a pKi of 10.2 for the human receptor. This orally active compound effectively crosses the blood-brain barrier, making it a valuable tool in neurological research. Orvepitant maleate shows promise for therapeutic applications in depressive disorders and chronic refractory cough (CRC), providing insights into the modulation of neurokinin pathways.
Orvepitant maleate is a potent and selective antagonist of the neurokinin-1 (NK-1) receptor, exhibiting a pKi of 10.2 for the human receptor. This orally active compound effectively crosses the blood-brain barrier, making it a valuable tool in neurological research. Orvepitant maleate shows promise for therapeutic applications in depressive disorders and chronic refractory cough (CRC), providing insights into the modulation of neurokinin pathways.
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