Fig. 1 · Structure
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Orvepitant
Neurokinin Receptor Antagonist
Orvepitant is a potent and selective neurokinin-1 (NK-1) receptor antagonist with a reported pKi of 10.2 for the human NK-1 receptor. This orally active compound is capable of crossing the blood-brain barrier, making it suitable for central nervous system applications. Orvepitant demonstrates potential therapeutic effects in the treatment of depressive disorders and chronic refractory cough (CRC), supporting its role in various neurological and respiratory research applications.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Antagonist |
| CAS Number | 579475-18-6 |
| Applications | Neurokinin Receptor Antagonist |
| Formula | C31H35F7N4O2 |
| Molecular Weight | 628.62 |
| Synonyms | GW823296 |
| SMILES | C[C@H](C1=CC(C(F)(F)F)=CC(C(F)(F)F)=C1)N(C)C(N2[C@@H](C3=C(C=C(C=C3)F)C)C[C@@H](N4C[C@@]5([H])N(C(CC5)=O)CC4)CC2)=O |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.