Osavampator (TAK-653) is a positive allosteric modulator of AMPA receptors that selectively binds in a glutamate-dependent manner. It enhances Ca²⁺ influx in hGluA1i CHO cells with an EC50 of 3.3 μM. Osavampator has been shown to improve learning and memory in various models and is under investigation for the treatment of depressive disorders.
Osavampator (TAK-653) is a positive allosteric modulator of AMPA receptors that selectively binds in a glutamate-dependent manner. It enhances Ca²⁺ influx in hGluA1i CHO cells with an EC50 of 3.3 μM. Osavampator has been shown to improve learning and memory in various models and is under investigation for the treatment of depressive disorders.
Store lyophilized at -20ºC, keep desiccated. In lyophilized form, the chemical is stable for 36 months. In solution, store at -20ºC and use within 1 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.
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