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OSI-7904L

Thymidylate Synthase Inhibitor

OSI-7904L is a noncompetitive inhibitor of thymidylate synthase (TS), functioning as an antifolate compound and a substrate for folylpolyglutamate synthetase. This compound exhibits significant cytotoxicity against various solid tumor cell lines, demonstrating its potential in cancer research and therapeutic applications. The cytotoxic effects of OSI-7904L can be selectively mitigated by folic acid, highlighting its mechanism of action and potential for targeted treatment strategies.

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Specifications

Manufacturer	Adooq Bioscience
Actions	Inhibitor
CAS Number	139987-54-5
Applications	Thymidylate Synthase Inhibitor
Formula	C₂₇H₂₄N₄O₆
Molecular Weight	500.50
Synonyms	GW1843; 1843U89; OSI-7904
SMILES	O=C1C2=C3C(C=CC(CNC4=CC=C(C(N(C5)[C@H](C(O)=O)CCC(O)=O)=O)C5=C4)=C3)=CC=C2NC(C)=N1

Storage & Solubility

In Vitro Solubility

Reported Solubility

No reported solubility data are available for this product.

Preparing Stock Solutions

Stock preparation is unavailable for this product molecular weight.

Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.

Storage

Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.