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Other Inhibitors groups bioactive small molecules whose targets fall outside the pathway categories of this catalogue. The compounds have not yet been assigned to target categories, so the range is broad and uneven. Streptozotocin, a glucosamine-nitrosourea compound used to induce experimental diabetes in rodents, sits beside the O-GlcNAcase inhibitor Thiamet G. Exherin is an N-cadherin antagonist, and AdipoRon is an agonist of adiponectin receptors 1 and 2 (AdipoR1 and AdipoR2). Plant compounds such as the isoflavone daidzein are also included. Despite the category name, not every compound is an inhibitor, as the AdipoRon example shows. Compounds with a well-defined target are usually listed in the matching pathway or target category.
D-cycloserine is a partial agonist at the glycine receptor, and has been shown to have cognition-enhancing properties for models of Parkinsons disease in primates.
Bilobalide, a biologically active terpenic trilactone (terpinoid), derived from geranylgeranyl pyrophosphate (GGPP) is an inducer of cytochrome P450 enzymes CYP3A1 and CYP1A2. May contain properties to stop apoptosis activation of the phosphatidylinositol 3-Kinase pathway in SH-SY5Y cells.
TOK-8801 is a synthesized dihydroimidazothiazole carboxamide and is under development as an immunomodulator.
Synonyms: LYC30937
Parimifasor (LYC30937) is an immunomodulator, with anti-inflammatory activity.
Neuropathiazol is a synthetic small molecule that induces neuronal differentiation of adult hippocampal neural progenitor cells.
Plumbagin, exhibits cytotoxicity in rodent models of carcinogenesis and carcinoma; has antifungal, antiviral, and antibacterial action.
Synonyms: Isoxazole 9
ISX-9 is a small molecule inducer of adult neural stem cell differentiation.
PZ-2891 is an orally bioavailable, brain penetrant pantothenate kinase (PANK) modulator. PZ-2891 act as an orthosteric inhibitor at high concentrations and an allosteric activator at lower sub-saturating concentrations. PZ-2891 inhibits human pantothenate kinases PANK1β, PANK2, and PANK3 with IC50s of 40.2 nM, 0.7 nM and 1.3 nM, respectively.
N-(beta-ketocaproyl)-L-Homoserine lactone (N-(Ketocaproyl)-L-homoserine lactone, N-(β-Ketocaproyl)-L-hoMoserine lactone) is an autoinducer of P. fischeri luciferase and a component of quorum regulatory sensing.
