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Gluconeogenesis

Gluconeogenesis research compounds relate to the production of sugars from non-carbohydrate precursors. This metabolic pathway is studied in hepatic and renal physiology, particularly during fasting and changes in nutrient availability. Fructose-1,6-bisphosphatase is one of the enzymes that provides a bypass around irreversible steps of glycolysis. FBPase-IN-1 is assigned here as an inhibitor of that enzyme. Methylenecyclopropylpyruvate is separately listed as a gluconeogenesis inhibitor, broadening the selection for research on pathway regulation and intermediary metabolism.

2 Items

  • FBPase-IN-1
    Cat. No.
    A74856
    CAS No.
    20362-54-3

    FBPase-IN-1

    FBPase-IN-1 is a selective inhibitor of fructose-1,6-bisphosphatase (FBPase) with an IC50 of 0.22 μM. This compound demonstrates significant efficacy in lowering blood glucose levels and improving glucose tolerance, making it a valuable tool for Type 2 diabetes research. FBPase-IN-1 targets the C128 site, modulating the N125-S124-S123 allosteric pathway and influencing the catalytic activity of FBPase, thus offering insights into metabolic regulation and potential therapeutic strategies.

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    1 mg
    $65.00
    5 mg
    $170.00
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  • Methylenecyclopropylpyruvate
    Cat. No.
    A76762
    CAS No.
    5746-24-7

    Methylenecyclopropylpyruvate

    Synonyms: Ketohypoglycin

    Methylenecyclopropylpyruvate is a potent inhibitor of gluconeogenesis, primarily impacting glucose metabolism. This compound modulates ketogenesis and fatty acid metabolism by interfering with mitochondrial β-oxidation pathways. Additionally, methylenecyclopropylpyruvate alters the levels and composition of coenzyme A, contributing to disrupted glucose homeostasis. Its biochemical effects make it a valuable tool for studying metabolic regulation and energy homeostasis.

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