Oxaprozin-d5 is a deuterium-labeled derivative of Oxaprozin, a nonsteroidal anti-inflammatory drug (NSAID) that functions as a dual inhibitor of cyclooxygenase enzymes COX-1 and COX-2, exhibiting IC50 values of 2.2 μM and 36 μM, respectively, for human platelet COX-1 and IL-1-stimulated human synovial cell COX-2. Additionally, Oxaprozin is known to inhibit the activation of NF-κB. This stable isotope can be utilized in pharmacokinetic studies and metabolic research, enhancing the understanding of Oxaprozin's biological pathways and mechanisms of action.
Oxaprozin-d5 is a deuterium-labeled derivative of Oxaprozin, a nonsteroidal anti-inflammatory drug (NSAID) that functions as a dual inhibitor of cyclooxygenase enzymes COX-1 and COX-2, exhibiting IC50 values of 2.2 μM and 36 μM, respectively, for human platelet COX-1 and IL-1-stimulated human synovial cell COX-2. Additionally, Oxaprozin is known to inhibit the activation of NF-κB. This stable isotope can be utilized in pharmacokinetic studies and metabolic research, enhancing the understanding of Oxaprozin's biological pathways and mechanisms of action.
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