Fig. 1 · Structure
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Oxidopamine hydrobromide
Neurotoxin
Oxidopamine hydrobromide is a selective neurotoxin that primarily targets dopaminergic neurons by antagonizing dopamine neurotransmission. This compound is crucial for studies investigating neurodegenerative disorders, such as Parkinson’s disease, as it induces neuroinflammation through COX-2 activation and subsequent PGE2 and IL-1β production. Oxidopamine hydrobromide is valuable in researching mechanisms underlying attention-deficit hyperactivity disorder and Lesch-Nyhan syndrome, enabling insights into dopaminergic dysfunction and its consequences.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| CAS Number | 636-00-0 |
| Applications | Neurotoxin |
| Formula | C8H12BrNO3 |
| Molecular Weight | 250.09 |
| Synonyms | 6-Hydroxydopamine hydrobromide; 6-OHDA hydrobromide |
| SMILES | OC1=CC(CCN)=C(O)C=C1O.[H]Br |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.