Fig. 1 · Structure
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Oxidopamine hydrochloride
Neurotoxin
Oxidopamine hydrochloride is a neurotoxin that selectively targets and destroys dopaminergic neurons by acting as a dopamine antagonist. This compound induces COX-2 activation, resulting in the synthesis of prostaglandin E2 and the secretion of pro-inflammatory cytokine IL-1β. Oxidopamine hydrochloride is primarily employed in research related to neurodegenerative disorders such as Parkinson's disease, attention-deficit hyperactivity disorder, and Lesch-Nyhan syndrome.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Antagonist |
| CAS Number | 28094-15-7 |
| Applications | Neurotoxin |
| Formula | C8H12ClNO3 |
| Molecular Weight | 205.64 |
| Synonyms | 6-Hydroxydopamine Hydrochloride |
| SMILES | OC1=CC(CCN)=C(O)C=C1O.[H]Cl |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.