Fig. 1 · Structure
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p-Ethynylphenylalanine hydrochloride
TPH Inhibitror
p-Ethynylphenylalanine hydrochloride is a selective, reversible, and competitive inhibitor of tryptophan hydroxylase (TPH), exhibiting a Ki value of 32.6 μM. This compound is notable for its utility in click chemistry applications, containing an alkyne group that participates in copper-catalyzed azide-alkyne cycloaddition (CuAAc) with azide-containing molecules. Its potent inhibition of TPH makes it valuable for research focused on serotonin biosynthesis and related metabolic pathways.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 188640-63-3 |
| Applications | TPH Inhibitror |
| Formula | C11H12ClNO2 |
| Molecular Weight | 225.67 |
| Synonyms | 4-Ethynyl-L-phenylalanine hydrochloride |
| SMILES | N[C@@H](CC1=CC=C(C#C)C=C1)C(O)=O.[H]Cl |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.