Fig. 1 · Structure
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p-Ethynylphenylalanine
TPH Inhibitror
p-Ethynylphenylalanine is a selective, reversible inhibitor of tryptophan hydroxylase (TPH), exhibiting a Ki value of 32.6 μM. This compound serves as a valuable click chemistry reagent, featuring an alkyne group that facilitates copper-catalyzed azide-alkyne cycloaddition (CuAAc) with azide-containing molecules. Its potent inhibitory effects on TPH make it suitable for research related to serotonin biosynthesis and related metabolic pathways.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 278605-15-5 |
| Applications | TPH Inhibitror |
| Formula | C11H11NO2 |
| Molecular Weight | 189.21 |
| Synonyms | 4-Ethynyl-L-phenylalanine |
| SMILES | N[C@@H](CC1=CC=C(C#C)C=C1)C(O)=O |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.