Fig. 1 · Structure
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p-SCN-Bn-NOTA trihydrochloride
Chelator
p-SCN-Bn-NOTA trihydrochloride is a macrocyclic chelator that forms stable complexes with metal ions, particularly suitable for radiolabeling applications. It can be covalently attached to peptides via the thiocyanate group, facilitating the formation of hexacoordinate copper complexes, such as with 64Cu. This compound binds selectively to GRPR and EGFR, which are overexpressed in various tumor cells, thereby enhancing the targeting of radioactive probes in tumor imaging and therapeutics. It is applicable in research focused on malignant tumors, including prostate and colorectal cancers.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| CAS Number | 1583289-85-3 |
| Applications | Chelator |
| Formula | C20H29Cl3N4O6S |
| Molecular Weight | 559.89 |
| SMILES | O=C(O)CN1C(CC2=CC=C(N=C=S)C=C2)CN(CC(O)=O)CCN(CC(O)=O)CC1.Cl.Cl.Cl |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.