P11149 is a competitive inhibitor of acetylcholinesterase (AChE) that exhibits weak oral bioavailability and the ability to penetrate the blood-brain barrier. With an IC50 of 1.3 μM against rat butyrylcholinesterase (BChE) and AChE, P11149 displays significant cholinergic activity and behavioral efficacy. This Galanthamine derivative is primarily used in research related to Alzheimer's disease, aiding in the exploration of therapeutic strategies for cognitive impairment associated with this neurodegenerative disorder.
P11149 is a competitive inhibitor of acetylcholinesterase (AChE) that exhibits weak oral bioavailability and the ability to penetrate the blood-brain barrier. With an IC50 of 1.3 μM against rat butyrylcholinesterase (BChE) and AChE, P11149 displays significant cholinergic activity and behavioral efficacy. This Galanthamine derivative is primarily used in research related to Alzheimer's disease, aiding in the exploration of therapeutic strategies for cognitive impairment associated with this neurodegenerative disorder.
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