Fig. 1 · Structure
Documents & Downloads
P11149
AChE Inhibitor
P11149 is a competitive inhibitor of acetylcholinesterase (AChE) that exhibits weak oral bioavailability and the ability to penetrate the blood-brain barrier. With an IC50 of 1.3 μM against rat butyrylcholinesterase (BChE) and AChE, P11149 displays significant cholinergic activity and behavioral efficacy. This Galanthamine derivative is primarily used in research related to Alzheimer's disease, aiding in the exploration of therapeutic strategies for cognitive impairment associated with this neurodegenerative disorder.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 164724-79-2 |
| Applications | AChE Inhibitor |
| Formula | C27H34ClNO4 |
| Molecular Weight | 472.02 |
| SMILES | O=C(C12C[C@H](C3)C[C@H](C[C@H]3C2)C1)OC4=CC=C5C6=C4O[C@]7([H])[C@@]6(CCN(C)C5)C=C[C@H](O)C7.[H]Cl |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.