Fig. 1 · Structure
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p53 Activator 2
DNA Double-Strand Break Inducer
p53 Activator 2 is a potent DNA double-strand break inducer that intercalates into DNA, leading to significant damage. This compound enhances the expression of key cell cycle regulators, including p53, p-p53, CDK4, and p21, resulting in G2/M phase cell cycle arrest and the induction of apoptosis. Additionally, it down-regulates anti-apoptotic proteins such as Bcl-2 and Bcl-xL, while reducing cyclin B1 levels. p53 Activator 2 exhibits strong anti-proliferative effects against MGC-803 cells, with an IC50 of 1.73 µM, and demonstrates notable anticancer efficacy in MGC-803 xenograft tumor models.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inducer |
| CAS Number | 2338764-89-7 |
| Applications | DNA Double-Strand Break Inducer |
| Formula | C20H21N5O2 |
| Molecular Weight | 363.41 |
| SMILES | NCCCCNC1=NC(/C=C/C2=CC=C([N+]([O-])=O)C=C2)=NC3=C1C=CC=C3 |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.