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P9R

Catalog No.: A50822
Antiviral Peptide
P9R is an antiviral peptide that exhibits broad-spectrum activity against multiple viruses, including coronaviruses (SARS-CoV-2, MERS-CoV, SARS-CoV), A(H1N1)pdm09, A(H7N9), and rhinovirus. Its primary mechanism involves direct binding to viral particles and inhibition of virus-host endosomal acidification, providing significant protection in murine models against A(H1N1)pdm09 infection without fostering drug resistance. P9R serves as a valuable research tool for studying pH-dependent respiratory viruses.
P9R 2484874-12-4 Antiviral Peptide
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Research use only. We do not sell to patients.
Data Sheet SDS Compound Handling Instructions

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Adooq Products cited in reputable paper
Science VOLUME 380, ISSUE 6663 (2023)
Science VOLUME 369, ISSUE 6510 (2020)
Science VOLUME 356, ISSUE 6336 (2017)
Cell Vol. 185 Issue 23 p4428-4447.e28
Cell Vol 177, Issue 7, p1933-1947.e25
Cell Vol 156, Issue 5, p857-1114
Nature Volume 622 Issue 7982 (2023)
Nature volume 620, pages890-897 (2023)
Nature volume 610, pages540-546 (2022)
Nature volume 588, pages83-88 (2020)
Nature volume 574, pages268-272 (2019)
Nature volume 573, pages539-545 (2019)
Nature volume 567, pages118-122 (2019)
Nature volume 551, pages639-643 (2017)
Nature volume 551, pages247-250 (2017)
Nature volume 548, pages356-360 (2017)
Nature volume 545, pages187-192 (2017)
Biological Activity
DescriptionP9R is an antiviral peptide that exhibits broad-spectrum activity against multiple viruses, including coronaviruses (SARS-CoV-2, MERS-CoV, SARS-CoV), A(H1N1)pdm09, A(H7N9), and rhinovirus. Its primary mechanism involves direct binding to viral particles and inhibition of virus-host endosomal acidification, providing significant protection in murine models against A(H1N1)pdm09 infection without fostering drug resistance. P9R serves as a valuable research tool for studying pH-dependent respiratory viruses.
Product Information
Catalog NumA50822
FormulaC144H232N52O35S5
Molecular Weight3412.04
CAS Number2484874-12-4
SequenceAsn-Gly-Ala-Ile-Cys-Trp-Gly-Pro-Cys-Pro-Thr-Ala-Phe-Arg-Gln-Ile-Gly-Asn-Cys-Gly-Arg-Phe-Arg-Val-Arg-Cys-Cys-Arg-Ile-Arg
Sequence shorteningNGAICWGPCPTAFRQIGNCGRFRVRCCRIR
SMILESC([C@H](NC([C@@H](NC([C@@H](NC([C@@H](NC(CNC([C@H](CC(N)=O)N)=O)=O)C)=O)[C@H](CC)C)=O)CS)=O)C(NCC(=O)N1[C@H](C(N[C@H](C(=O)N2[C@H](C(N[C@H](C(N[C@H](C(N[C@@H](CC3=CC=CC=C3)C(N[C@H](C(N[C@H](C(N[C@H](C(NCC(N[C@H](C(N[C@H](C(NCC(N[C@H](C(N[C@@H](CC4=CC=CC=C4)C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@@H](CCCNC(=N)N)C(O)=O)=O)[C@H](CC)C)=O)CCCNC(=N)N)=O)CS)=O)CS)=O)CCCNC(=N)N)=O)C(C)C)=O)CCCNC(=N)N)=O)=O)CCCNC(=N)N)=O)=O)CS)=O)CC(N)=O)=O)=O)[C@H](CC)C)=O)CCC(N)=O)=O)CCCNC(=N)N)=O)=O)C)=O)[C@@H](C)O)=O)CCC2)CS)=O)CCC1)=O)C=5C=6C(NC5)=CC=CC6
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