PAO-Nap is a selective thioredoxin reductase (TrxR) inhibitor modified with a naphthalimide fluorophore linked via aminocaproic acid. This compound induces oxidative stress-mediated apoptosis in HL-60 cells, making it a valuable tool for studying apoptotic pathways and oxidative stress mechanisms in cancer research. Its unique fluorescent properties also facilitate real-time monitoring of cellular responses to TrxR inhibition.
PAO-Nap is a selective thioredoxin reductase (TrxR) inhibitor modified with a naphthalimide fluorophore linked via aminocaproic acid. This compound induces oxidative stress-mediated apoptosis in HL-60 cells, making it a valuable tool for studying apoptotic pathways and oxidative stress mechanisms in cancer research. Its unique fluorescent properties also facilitate real-time monitoring of cellular responses to TrxR inhibition.
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