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Paromomycin

Antimalarial Agent

Paromomycin is an aminoglycoside antibiotic that primarily targets the 16S rRNA A-site, leading to alterations in ribosomal conformation and ultimately inhibiting protein synthesis. This compound exhibits significant antimalarial activity and demonstrates efficacy against various parasitic infections, including those caused by Leishmania species, Entamoeba histolytica, and Cryptosporidium parvum. Paromomycin is a valuable tool for researchers exploring therapeutic strategies for leishmaniasis, amoebiasis, and cryptosporidiosis.

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Specifications

Manufacturer	Adooq Bioscience
CAS Number	7542-37-2
Applications	Antimalarial Agent
Formula	C₂₃H₄₅N₅O₁₄
Molecular Weight	615.63
Synonyms	Aminosidine
SMILES	O[C@H]([C@@H]([C@H](O1)CO)O[C@H]2O[C@H]([C@H]([C@@H]([C@H]2N)O)O)CN)[C@@H]1O[C@H]([C@H]([C@@H](C[C@@H]3N)N)O)[C@@H]3O[C@H]4O[C@@H]([C@H]([C@@H]([C@H]4N)O)O)CO

Storage & Solubility

In Vitro Solubility

Reported Solubility

No reported solubility data are available for this product.

Preparing Stock Solutions

Stock preparation is unavailable for this product molecular weight.

Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.

Storage

Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.