Fig. 1 · Structure
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PARPYnD
Photoaffinity Probe
PARPYnD is a photoaffinity probe for the poly(ADP-ribose) polymerase (PARP) family, specifically targeting PARP1, PARP2, and PARP6. This compound demonstrates significant biological activity with IC50 values of 38 nM for PARP1, 6 nM for PARP2, and 230 nM for PARP6. PARPYnD is effective in enriching recombinant PARP6 in cell lysates and inhibiting its activity in cell-free assays, making it a valuable tool for research in cancer biology, particularly in studies involving multipolar spindle formation in breast cancer cells. However, it does not label PARP6 in intact cellular environments.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| CAS Number | 2561483-27-8 |
| Applications | Photoaffinity Probe |
| Formula | C34H31N9O3 |
| Molecular Weight | 613.67 |
| SMILES | N#CC1=CC(NC(CCC2(CCC#C)N=N2)=O)=CN=C1N3CCN(CC3)C(C4=CC=CC(CC5=NNC(C6=C5C=CC=C6)=O)=C4)=O |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.