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PAT-078

ATX Inhibitor

PAT-078 is a type II autotaxin (ATX) inhibitor that effectively occupies the hydrophobic pocket of ATX. By obstructing the bottleneck region between the hydrophobic channel and the catalytic site, PAT-078 inhibits ATX activity without binding to the zinc ion at the catalytic site. This compound is valuable for research exploring the roles of ATX in various biological processes and disease states, making it a significant tool for investigating therapeutic interventions.

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Specifications

Manufacturer	Adooq Bioscience
Actions	Inhibitor
CAS Number	1682644-84-3
Applications	ATX Inhibitor
Formula	C₂₅H₁₆ClFN₂O₂
Molecular Weight	430.86
SMILES	C(=C(\C#N)/C1=CC=C(C(O)=O)C=C1)\C=2C=3C(N(CC4=CC=C(F)C=C4)C2)=CC(Cl)=CC3

Storage & Solubility

In Vitro Solubility

Reported Solubility

No reported solubility data are available for this product.

Preparing Stock Solutions

Stock preparation is unavailable for this product molecular weight.

Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.

Storage

Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.