PB94 is a selective inhibitor of histone deacetylase 11 (HDAC11), with an IC₅₀ of 108 nM. It can be radiolabeled as [¹¹C]-PB94 for positron emission tomography (PET) imaging, enabling in vivo assessment of brain uptake and metabolic properties. PB94 has demonstrated efficacy in alleviating neuropathic pain in mouse models and holds potential as a research tool for investigating HDAC11-related mechanisms in neurological disorders.
PB94 is a selective inhibitor of histone deacetylase 11 (HDAC11), with an IC₅₀ of 108 nM. It can be radiolabeled as [¹¹C]-PB94 for positron emission tomography (PET) imaging, enabling in vivo assessment of brain uptake and metabolic properties. PB94 has demonstrated efficacy in alleviating neuropathic pain in mouse models and holds potential as a research tool for investigating HDAC11-related mechanisms in neurological disorders.
Store lyophilized at -20ºC, keep desiccated. In lyophilized form, the chemical is stable for 36 months. In solution, store at -20ºC and use within 1 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.
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