PD 136450 is a potent antagonist of cholecystokinin 2 (CCK2) receptors. This compound demonstrates significant biological activity, including anti-secretory, anxiolytic, and anti-ulcer effects. PD 136450 effectively inhibits gastric acid secretion with an IC50 of 1 mg/kg and significantly reduces hemorrhagic lesions in rat models, with an IC50 of 4.7 mg/kg. It is a valuable tool for investigating gastrointestinal disorders and evaluating potential therapeutic approaches in related pharmacological research.
PD 136450 is a potent antagonist of cholecystokinin 2 (CCK2) receptors. This compound demonstrates significant biological activity, including anti-secretory, anxiolytic, and anti-ulcer effects. PD 136450 effectively inhibits gastric acid secretion with an IC50 of 1 mg/kg and significantly reduces hemorrhagic lesions in rat models, with an IC50 of 4.7 mg/kg. It is a valuable tool for investigating gastrointestinal disorders and evaluating potential therapeutic approaches in related pharmacological research.
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