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PD 136450

CCK2 Antagonist

PD 136450 is a potent antagonist of cholecystokinin 2 (CCK2) receptors. This compound demonstrates significant biological activity, including anti-secretory, anxiolytic, and anti-ulcer effects. PD 136450 effectively inhibits gastric acid secretion with an IC50 of 1 mg/kg and significantly reduces hemorrhagic lesions in rat models, with an IC50 of 4.7 mg/kg. It is a valuable tool for investigating gastrointestinal disorders and evaluating potential therapeutic approaches in related pharmacological research.

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Specifications

Manufacturer	Adooq Bioscience
Actions	Antagonist
CAS Number	139067-52-0
Applications	CCK2 Antagonist
Formula	C₃₅H₄₀N₄O₆
Molecular Weight	612.72
Synonyms	CAM 1189
SMILES	O=C(/C=C/C(N[C@@H](CNC([C@@](C)(CC1=CNC2=C1C=CC=C2)NC(OC3C4CC(CC3C5)CC5C4)=O)=O)C6=CC=CC=C6)=O)O

Storage & Solubility

In Vitro Solubility

Reported Solubility

No reported solubility data are available for this product.

Preparing Stock Solutions

Stock preparation is unavailable for this product molecular weight.

Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.

Storage

Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.