Fig. 1 · Structure
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PD 144418
σ1 Receptor Ligand
PD 144418 is a potent and selective sigma 1 (σ1) receptor ligand, exhibiting a high affinity with a Ki value of 0.08 nM for σ1 and significantly lower affinity of 1377 nM for σ2 receptors. This compound demonstrates minimal interaction with other receptors, ion channels, and enzymes, ensuring specificity in its action. PD 144418 has shown potential antipsychotic properties, making it a valuable tool for research into psychiatric disorders and sigma receptor biology.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Ligand / Binder |
| CAS Number | 154130-99-1 |
| Applications | σ1 Receptor Ligand |
| Formula | C18H22N2O |
| Molecular Weight | 282.38 |
| SMILES | CCCN1CC(C2=CC(C3=CC=C(C)C=C3)=NO2)=CCC1 |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.