Fig. 1 · Structure
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Pentamidine dihydrochloride
Antimicrobial Agent
Pentamidine dihydrochloride is an antimicrobial agent that targets DNA biosynthesis. It exhibits potent inhibition of Leishmania infantum with an IC50 value of 2.5 μM. Additionally, it selectively inhibits protein tyrosine phosphatases (PTPases) and phosphatase of regenerating liver (PRL), demonstrating potential applications in the treatment of Gambian trypanosomiasis, antimony-resistant leishmaniasis, and Pneumocystis carinii pneumonia. Furthermore, Pentamidine dihydrochloride possesses notable antitumor and antibacterial activities.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| CAS Number | 50357-45-4 |
| Applications | Antimicrobial Agent |
| Formula | C19H26Cl2N4O2 |
| Molecular Weight | 413.34 |
| Synonyms | MP-601205 dihydrochloride |
| SMILES | N=C(C1=CC=C(OCCCCCOC2=CC=C(C(N)=N)C=C2)C=C1)N.Cl.Cl |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.