Fig. 1 · Structure
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Pentamidine dimesylate
Antimicrobial Agent
Pentamidine dimesylate is an antimicrobial agent that targets DNA biosynthesis. It demonstrates significant inhibitory activity against the parasite Leishmania infantum, with an IC50 of 2.5 μM. This compound also selectively inhibits protein tyrosine phosphatases (PTPases) and phosphatase of regenerating liver (PRL), indicating its potential in the treatment of Gambian trypanosomiasis, antimony-resistant leishmaniasis, and Pneumocystis carinii pneumonia. Additionally, pentamidine dimesylate exhibits notable antitumor and antibacterial properties, making it a valuable tool for biological research and therapeutic applications.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| CAS Number | 6823-79-6 |
| Applications | Antimicrobial Agent |
| Formula | C21H32N4O8S2 |
| Molecular Weight | 532.63 |
| Synonyms | MP-601205 dimesylate |
| SMILES | N=C(N)C1=CC=C(C=C1)OCCCCCOC2=CC=C(C=C2)C(N)=N.OS(=O)(C)=O.OS(=O)(C)=O |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.