Pentoxyverine is an orally active sigma-1 receptor agonist, exhibiting affinity with Kis of 41 nM for σ1, 894 nM for σ2, and 75 nM for guinea-pig brain membran σ1. This compound acts as a muscarinic antagonist and demonstrates significant biological activities, including antitussive, anticonvulsant, and spasmolytic effects. Pentoxyverine is utilized in research for its potential to inhibit bronchial interceptors, diminish the cough reflex, induce relaxation of bronchial smooth muscle, and reduce airway resistance in various pulmonary conditions.
Pentoxyverine is an orally active sigma-1 receptor agonist, exhibiting affinity with Kis of 41 nM for σ1, 894 nM for σ2, and 75 nM for guinea-pig brain membran σ1. This compound acts as a muscarinic antagonist and demonstrates significant biological activities, including antitussive, anticonvulsant, and spasmolytic effects. Pentoxyverine is utilized in research for its potential to inhibit bronchial interceptors, diminish the cough reflex, induce relaxation of bronchial smooth muscle, and reduce airway resistance in various pulmonary conditions.
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