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Biological Activity
PF-00446687 is a potent, selective melanocortin-4 receptor (MC4R) agonist with EC50 of 12????1 nM. Pf-446687 is brain penetrant.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 21.25 mL | 106.25 mL | 212.5 mL |
| 0.5 mM | 4.25 mL | 21.25 mL | 42.5 mL |
| 1 mM | 2.12 mL | 10.62 mL | 21.25 mL |
| 5 mM | 0.42 mL | 2.12 mL | 4.25 mL |
*The above data is based on the productmolecular weight 470.59. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Catalog Num | A21382 |
|---|---|
| Actions | Agonist |
| CAS No. | 862281-92-3 |
| Formula | C28H36F2N2O2 |
| M. Wt | 470.59 |
| Purity | >98% |
| Synonyms | PF00446687, PF 00446687 |
| SMILES | O=C([C@H]1[C@H](C2=C(C=C(F)C=C2)F)CN(C(C)(C)C)C1)N3C[C@H]([C@](O)(C4=CC=CC=C4)[C@@H](C)C3)C |
| Storage | Store lyophilized at -20ºC, keep desiccated. |
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