Fig. 1 · Structure
Documents & Downloads
PF-00835231
3CLpro Inhibitor
PF-00835231 is a potent inhibitor of the SARS-CoV-2 cysteine 3C-like protease (3CLpro), exhibiting IC50 values of 0.27 nM for SARS-CoV-2 and 4 nM for SARS-CoV-1 3CLpro. This compound is designed for anti-SARS-CoV-2 and COVID-19 research, demonstrating the capability to inhibit viral infections in vitro and reduce viral load in animal models. PF-00835231 serves as a valuable tool for studying the mechanisms of viral replication and potential therapeutic strategies against coronavirus infections.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 870153-29-0 |
| Applications | 3CLpro Inhibitor |
| Formula | C24H32N4O6 |
| Molecular Weight | 472.53 |
| SMILES | O=C(C(N1)=CC2=C1C=CC=C2OC)N[C@H](C(N[C@@H](C[C@H]3C(NCC3)=O)C(CO)=O)=O)CC(C)C |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.