Fig. 1 · Structure
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PF-03463275
GlyT1 Inhibitor
PF-03463275 is a selective and competitive inhibitor of glycine transporter-1 (GlyT1) with a Ki of 11.6 nM. This centrally penetrant and orally available compound demonstrates potential for advancing research in schizophrenia by modulating glycine levels in the central nervous system. Its efficacy in targeting GlyT1 makes it a valuable tool for understanding the mechanisms underlying this neuropsychiatric disorder.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 1173239-39-8 |
| Applications | GlyT1 Inhibitor |
| Formula | C19H22ClFN4O |
| Molecular Weight | 376.86 |
| SMILES | O=C(C(N=C1)=CN1C)N(CC(C=C2)=CC(Cl)=C2F)C[C@@H]3[C@](C4)([H])[C@@]3([H])CN4C |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.