Fig. 1 · Structure
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PF-04859989
Kynurenine Aminotransferase Inhibitor
PF-04859989 is an irreversible inhibitor of kynurenine aminotransferase II (KAT II), demonstrating significant brain penetration. It exhibits IC50 values of 23 nM and 263 nM for human KAT II and rabbit KAT II, respectively, and shows high selectivity for KAT II over KAT I, KAT III, and KAT IV, with IC50 values greater than 11 μM. This compound is valuable for research into metabolic pathways involving kynurenine and the potential therapeutic implications for neurological disorders.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 34783-48-7 |
| Applications | Kynurenine Aminotransferase Inhibitor |
| Formula | C9H10N2O2 |
| Molecular Weight | 178.19 |
| SMILES | O=C1N(O)C2=C(C=CC=C2)C[C@@H]1N |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.