Fig. 1 · Structure
Documents & Downloads
PF-05214030
Cat. No.
A68730
CAS
1669444-50-1
TRPV4 Antagonist
PF-05214030 is a potent TRPV4 antagonist, exhibiting IC50 values of 4 nM for human TRPV4 and 27 nM for rat TRPV4. This compound effectively counteracts the decrease in bladder capacity induced by intravesical administration of a TRPV4 agonist. PF-05214030 is therefore a valuable tool for investigating the role of TRPV4 in bladder physiology and may hold potential for therapeutic applications in bladder dysfunction research.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Antagonist |
| CAS Number | 1669444-50-1 |
| Applications | TRPV4 Antagonist |
| Formula | C17H13Cl2FN2O4S |
| Molecular Weight | 431.27 |
| SMILES | N#CC1=CC=C(C=C1F)OCC2(CN(S(=O)(C3=CC=C(C=C3Cl)Cl)=O)C2)O |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.