PF-4136309

Catalog No.: A15127

CCR2 antagonist

PF-4136309

PF-4136309 Chemical Structure

CAS NO. 1341224-83-6

PF-4136309 is a potent, selective, and orally bioavailable CCR2 antagonist, with IC50s of 5.2 nM, 17 nM and 13 nM for human, mouse and rat CCR2.

Availability: In stock

Package Price Qty
5 mg
$72.00
10 mg
$124.00
50 mg
$368.00
100 mg
$736.00
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Warning Products are for laboratory research use only. Not for human use. We do not sell to patients.

Biological Activity

PF-4136309 is a potent, selective, and orally bioavailable CCR2 antagonist, with IC50s of 5.2 nM, 17 nM and 13 nM for human, mouse and rat CCR2.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 17.59 mL 87.94 mL 175.87 mL
0.5 mM 3.52 mL 17.59 mL 35.17 mL
1 mM 1.76 mL 8.79 mL 17.59 mL
5 mM 0.35 mL 1.76 mL 3.52 mL

*The above data is based on the productmolecular weight 568.59. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Catalog Num A15127
Actions Antagonist
CAS No. 1341224-83-6
Formula C29H31F3N6O3
M. Wt 568.59
Purity >98%
Synonyms INCB8761
SMILES O[[email protected]]1(CC[[email protected]](CC1)([H])N[[email protected]@H]2CN(CC2)C(CNC(C3=CC=CC(C(F)(F)F)=C3)=O)=O)C4=NC=C(C=C4)C5=NC=CC=N5
Storage

Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for 36 months.
In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

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