Fig. 1 · Structure
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(s)-PF-4136309
Isomer
(s)-PF-4136309 is the isomer of the CCR2 antagonist PF-4136309, serving as an effective experimental control in research settings. This compound exhibits high potency and selectivity, with IC50 values of 5.2 nM, 17 nM, and 13 nM for human, mouse, and rat CCR2, respectively. Its selective inhibition of CCR2 makes it valuable for studying inflammatory responses and related pathologies.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Antagonist |
| CAS Number | 1372407-07-2 |
| Applications | Isomer |
| Formula | C29H31F3N6O3 |
| Molecular Weight | 568.59 |
| Synonyms | (s)-INCB8761 |
| SMILES | O[C@]1(CC[C@@](CC1)([H])N[C@@H]2CN(CC2)C(CNC(C3=CC=CC(C(F)(F)F)=C3)=O)=O)C4=NC=C(C=C4)C5=NC=CC=N5 |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.