Fig. 1 · Structure
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PF-4348235
M3 Antagonist
PF-4348235 is a potent M3 muscarinic receptor antagonist. It demonstrates strong inhibitory activity against the human cloned M3 receptor with a Ki value of 0.73 nM, while also acting as a β2 adrenoceptor agonist with an EC50 of 3.7 nM. This compound is primarily utilized in research related to chronic obstructive pulmonary disease (COPD) due to its significant bronchodilator properties. Its dual action makes it a valuable tool in the study of respiratory disorders.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Antagonist |
| CAS Number | 1017857-38-3 |
| Applications | M3 Antagonist |
| Formula | C36H49ClN4O7S |
| Molecular Weight | 717.31 |
| Synonyms | β2AR/M-receptor agonist-2 |
| SMILES | O[C@H](C1=CC(NS(C)(=O)=O)=C(C=C1)O)CNCCCCCCCCCN(CC2)CCC2OC(NC3=C(C4=CC(Cl)=C(C=C4)O)C=CC=C3)=O |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.