Fig. 1 · Structure
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PG 116800
MMP Inhibitor
PG 116800 is an orally active inhibitor of matrix metalloproteinases (MMPs), exhibiting a high affinity for MMP-2, -3, -8, -9, -13, and -14, while showing significantly lower affinity for MMP-1 and -7. This compound demonstrates notable biological activity in modulating enzymatic processes involved in extracellular matrix degradation. PG 116800 is primarily utilized in research applications related to knee osteoarthritis, providing insights into potential therapeutic strategies for joint-related pathologies.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 291533-11-4 |
| Applications | MMP Inhibitor |
| Formula | C24H27N3O7S |
| Molecular Weight | 501.55 |
| Synonyms | PG 530742; PGE 530742; PGE 7113313 |
| SMILES | OC(C(NS(=O)(C1=CC=C(NC(C2=CC=C(OC)C=C2)=O)C=C1)=O)CC#CCN3CCOCC3)=O |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.