Fig. 1 · Structure
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Phallacidin
F-actin Stabilizer
Phallacidin is a bicyclic heptapeptide that acts as an F-actin stabilizer by binding with high affinity (Kd of 20 nM) to filamentous actin. This binding inhibits the depolymerization of F-actin and enhances the stability of microfilament structures, thereby protecting them from disruption by agents such as cytochalasins. When conjugated with a fluorophore, Phallacidin functions as a specific fluorescent probe, allowing for precise visualization of actin distribution within the cytoskeleton, including structures like stress fibers and cortical peripheral bands, using fluorescence microscopy.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Stabilizer |
| CAS Number | 26645-35-2 |
| Applications | F-actin Stabilizer |
| Formula | C37H50N8O13S |
| Molecular Weight | 846.90 |
| SMILES | [H][C@@]12C[C@H](O)CN1C(=O)[C@]1([H])CSc3[nH]c4ccccc4c3C[C@]([H])(NC(=O)[C@H](C)NC2=O)C(=O)N[C@@H](CC(C)(O)CO)C(=O)N[C@@H](C(C)C)C(=O)N[C@]([H])([C@H](O)C(O)=O)C(=O)N1 |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.