Fig. 1 · Structure
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Pheanthine
Antiplasmodial Agent
Pheanthine is an antiplasmodial agent that targets chloroquine-resistant Plasmodium falciparum K-1, exhibiting an IC50 of 0.8 μM, and effectively inhibits chloroquine-sensitive P. falciparum strain NF54 A19A with an IC50 of 0.03 μM. Additionally, Pheanthine demonstrates low cytotoxicity, with an IC50 of 11.2 μM in human lung fibroblast (MRC-5) cells and 8 μM in macrophages (PMM). This compound is of interest for researchers investigating malaria therapeutics and the development of new antiplasmodial strategies.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| CAS Number | 1263-79-2 |
| Applications | Antiplasmodial Agent |
| Formula | C38H42N2O6 |
| Molecular Weight | 622.75 |
| SMILES | COC1=C(OC(C=C2C(CC3)=C4)=C4OC)C([C@@](N5C)([H])CC(C=C6OC(C=C7)=CC=C7C[C@@]2([H])N3C)=CC=C6OC)=C(CC5)C=C1OC |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.