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PHGDH-IN-4

PHGDH Inhibitor

PHGDH-IN-4 is a selective inhibitor of phosphoglycerate dehydrogenase (PHGDH), a key enzyme in the serine biosynthetic pathway. This compound demonstrates significant inhibitory activity, making it a valuable tool in the study of cancer metabolism and therapeutic targets. Its role in modulating serine levels can aid in understanding tumor biology and exploring potential treatment options for various cancer types.

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Specifications

Manufacturer	Adooq Bioscience
Actions	Inhibitor
CAS Number	2132969-16-3
Applications	PHGDH Inhibitor
Formula	C₂₁H₁₉Cl₂N₃O₅S
Molecular Weight	496.36
SMILES	O=C(C1=CC2=C(N1C)C=CC(Cl)=C2Cl)NC3(COC3)C4=CC=C(S(=O)(NC(C)=O)=O)C=C4

Storage & Solubility

In Vitro Solubility

Reported Solubility

No reported solubility data are available for this product.

Preparing Stock Solutions

Stock preparation is unavailable for this product molecular weight.

Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.

Storage

Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.