Fig. 1 · Structure
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PHGDH-IN-5
PHGDH Inhibitor
PHGDH-IN-5 is a covalent inhibitor of phosphoglycerate dehydrogenase (PHGDH), demonstrating an IC50 value of 0.29 μM. This compound effectively inhibits cell proliferation in cancer cell lines that overexpress PHGDH, making it valuable for studying cancer metabolism. Additionally, PHGDH-IN-5 reduces serine production from glucose in MDA-MB-468 cells, highlighting its potential applications in oncology and metabolic research.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 17402-86-7 |
| Applications | PHGDH Inhibitor |
| Formula | C8H5NO4S |
| Molecular Weight | 211.19 |
| SMILES | O=S1(C2=CC=CC([N+]([O-])=O)=C2C=C1)=O |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.