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Photosensitizer-8

Photosensitizer

Photosensitizer-8 is an ALP-activatable photosensitizer based on a 2-anthrol derivative. Upon exposure to alkaline phosphatase (ALP), it undergoes hydrolysis to release the active photosensitizer 2-anthrol, demonstrating potent cytotoxicity against ALP-overexpressing cancer cell lines such as HeLa, A549, and HCT116, with IC50 values of 14.3 μM, 21.6 μM, and 17.5 μM, respectively. Notably, it exhibits minimal cytotoxic effects towards normal lung fibroblasts (WI-38), making it a promising candidate for photodynamic therapy research focused on ALP-overexpressing cancers.

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Specifications

Manufacturer	Adooq Bioscience
CAS Number	3106369-28-9
Applications	Photosensitizer
Formula	C₁₄H₁₁O₄P
Molecular Weight	274.21
SMILES	O=P(O)(O)OC1=CC2=CC3=CC=CC=C3C=C2C=C1

Storage & Solubility

In Vitro Solubility

Reported Solubility

No reported solubility data are available for this product.

Preparing Stock Solutions

Stock preparation is unavailable for this product molecular weight.

Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.

Storage

Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.