Fig. 1 · Structure
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PHPS1 sodium
Shp2 Inhibitor
PHPS1 sodium is a potent and selective inhibitor of the protein tyrosine phosphatase Shp2, with a competitive inhibition constant (Ki) of 0.73 μM. It exhibits specificity over related phosphatases, including Shp1, PTP1B, and the mutant Shp2-R362K, with Ki values of 5.8 μM, 10.7 μM, and 5.8 μM, respectively. This compound is valuable for studies in cancer research, particularly those involving signaling pathways mediated by Shp2, and can be utilized in evaluating potential therapeutic interventions in diseases associated with aberrant Shp2 activity.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 1177131-02-0 |
| Applications | Shp2 Inhibitor |
| Formula | C21H14N5NaO6S |
| Molecular Weight | 487.42 |
| SMILES | O=S(C1=CC=C(N/N=C2C(C3=CC=C([N+]([O-])=O)C=C3)=NN(C4=CC=CC=C4)C\2=O)C=C1)(O[Na])=O |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.