Akt

Cat. No.

A14475

CAS No.

23513-15-7

10-Gingerol

10-Gingerol is an AMPK agonist derived from ginger oleoresin, exhibiting notable anti-inflammatory, antioxidant, and anti-proliferative properties. It effectively suppresses neointimal hyperplasia and inhibits the proliferation of vascular smooth muscle cells. Demonstrating significant radical scavenging activities, 10-Gingerol has IC50 values of 10.47 μM against DPPH, 1.68 μM against superoxide, and 1.35 μM against hydroxyl radicals. This compound also inhibits MDA-MB-231 tumor cell line proliferation with an IC50 of 12.1 μM, while targeting the PI3K/Akt signaling pathway to suppress proliferation, migration, invasion, and promote apoptosis. It holds potential for research applications in ulcerative colitis.

Cat. No.

A24106

CAS No.

2603461-70-5

SY-LB-35

SY-LB-35 is a potent agonist of bone morphogenetic protein (BMP) receptors, capable of activating both canonical and non-canonical signaling pathways. In the C2C12 myoblast cell line, SY-LB-35 significantly enhances cell proliferation and viability, promoting cell cycle progression by increasing the proportion of cells in the S and G2/M phases. Mechanistically, it activates the canonical Smad pathway as well as non-canonical PI3K/Akt, ERK, p38, and JNK signaling cascades. These properties make SY-LB-35 a valuable tool for studying BMP-related cellular processes and a potential therapeutic candidate for tissue regeneration and muscle repair.

Cat. No.

A24192

CAS No.

286935-60-2

Gambogic amide

Gambogic amide is a potent and selective TrkA agonist that induces tyrosine phosphorylation of TrkA and activates downstream signaling pathways, including Akt and MAPK. It specifically binds to the cytoplasmic juxtamembrane domain of TrkA, promoting receptor dimerization and activation. Gambogic amide exhibits neuroprotective effects by preventing glutamate-induced neuronal cell death and demonstrates improved efficacy in a transient middle cerebral artery occlusion (MCAO) model of stroke, supporting its potential use in research on neurodegenerative diseases and stroke.

Cat. No.

A25947

CAS No.

78860-34-1

Demethylasterriquinone B1

Synonyms: DAQ B1; L-783281; Dimethylasterriquinone

Demethylasterriquinone B1 is an orally active insulin receptor agonist that functions as an AKT activator. This compound enhances eNOS expression and activity, resulting in increased nitric oxide production, while simultaneously downregulating the NADPH oxidase subunit p22phox to mitigate oxidative stress and improve vascular endothelial function. Additionally, Demethylasterriquinone B1, when combined with an AKT inhibitor, can modulate the insulin signaling pathway to activate antiviral pathways, including RNA interference and JAK/STAT, in mosquitoes, thereby demonstrating potential in reducing Zika virus infection.

Cat. No.

A31961

CAS No.

35285-69-9

Propylparaben sodium

Synonyms: Propyl parahydroxybenzoate sodium; Propyl 4-hydroxybenzoate sodium

Propylparaben sodium acts as a weak estrogen receptor agonist and serves as a voltage-gated sodium channel blocker, while also modulating the PI3K-AKT and JNK signaling pathways. It is known to induce oxidative stress, affecting the estrous cycle and hormone levels, as well as ovarian reserve function. Propylparaben sodium can inhibit the growth of antral follicles and influence the accumulation of steroid hormones in follicle culture media. This compound is suitable for research related to ovarian aging and myocardial ischemia-reperfusion injury.