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PDK1

PDK1 inhibitors act on 3-phosphoinositide-dependent protein kinase 1 (PDK1), an upstream growth-signaling kinase. PDK1 was characterized as the kinase that phosphorylates and activates protein kinase B (AKT) once phosphoinositide lipids accumulate at the membrane. It also phosphorylates the activation loop of related kinases in the protein kinase A, G and C (AGC) group, including p70 S6 kinase and protein kinase C isoforms. Listed inhibitors include GSK 2334470 and OSU-03012, while BX-795 and BX-912 also block other kinases. PHT-427 targets both AKT and PDK1, and PS 48 is a PDK1 activator used to study the opposite effect.

Cat. No.

A79779

CAS No.

96799-02-9

3-Amino-5-(2-furyl)pyrazole

Synonyms: 5-(Furan-2-yl)-1H-pyrazol-3-amine

3-Amino-5-(2-furyl)pyrazole is a PDK1 binder with an IC50 of 313 μM, demonstrating its potential to modulate PDK1 activity. This compound is primarily utilized in cancer research, aiding in the investigation of signaling pathways associated with tumorigenesis. Researchers may find it valuable for studying the role of PDK1 in cancer cell proliferation and survival.

In stock View Details

100 mg

$20.00

All 1 sizes

PDK1

3-Amino-5-(2-furyl)pyrazole