Pico145

Catalog No.: A13344

TRPC1/4/5 channels inhibitor

Pico145

Pico145 Chemical Structure

CAS NO. 1628287-16-0

Pico145 is a remarkable inhibitor of TRPC1/4/5 channels, inhibits (?)-englerin A-activated TRPC4/TRPC5 channels, with IC50s of 0.349 and 1.3 nM in cells, and shows no effect on TRPC3, TRPC6, TRPV1, TRPV4, TRPA1, TRPM2, TRPM8.

Availability: In stock

Package Price Qty
5 mg
$270.00
10 mg
$465.00
50 mg
$1,380.00
100 mg
$2,760.00
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Biological Activity

Pico145 is a remarkable inhibitor of TRPC1/4/5 channels, inhibits (?)-englerin A-activated TRPC4/TRPC5 channels, with IC50s of 0.349 and 1.3 nM in cells, and shows no effect on TRPC3, TRPC6, TRPV1, TRPV4, TRPA1, TRPM2, TRPM8.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 19.05 mL 95.26 mL 190.52 mL
0.5 mM 3.81 mL 19.05 mL 38.1 mL
1 mM 1.91 mL 9.53 mL 19.05 mL
5 mM 0.38 mL 1.91 mL 3.81 mL

*The above data is based on the productmolecular weight 524.88. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Catalog Num A13344
Actions Inhibitor
CAS No. 1628287-16-0
Formula C23H20ClF3N4O5
M. Wt 524.88
Solubility DMSO
Purity >98%
Synonyms HC-608, HC608, HC 608, Pico-145, Pico 145
SMILES O=C1C2=C(N=C(OC3=CC=CC(OC(F)(F)F)=C3)N2CC4=CC=C(Cl)C=C4)N(C)C(N1CCCO)=O
Storage

Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for 36 months.
In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

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